Recommend individuals not to adjust the dose of acetaminophen and codeine phosphate tablets without consulting a physician or other Health care Expert.
Codeine A study in rats and rabbits noted no teratogenic result of codeine administered over the duration of organogenesis in doses starting from five to 120 mg/kg. In the rat, doses within the a hundred and twenty mg/kg stage, inside the toxic variety for that adult animal, ended up associated with an increase in embryo resorption at some time of implantation.
Quite a few acute suffering situations (e.g., the discomfort that occurs with a variety of surgical processes or acute musculoskeletal accidents) call for no quite a lot of days of an opioid analgesic. Clinical guidelines on opioid prescribing for some acute discomfort conditions are available.
After stopping a CYP2D6 inhibitor, as the effects in the inhibitor decline, the codeine plasma concentration will reduce though the Energetic metabolite morphine plasma focus will improve, which could improve or extend adverse reactions and could induce potentially fatal respiratory melancholy (see CLINICAL PHARMACOLOGY).
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Codeine leads to a reduction in motility connected to an increase in smooth muscle mass tone within the antrum of the tummy and duodenum. Digestion of food from the compact intestine is delayed and propulsive contractions are lessened.
If a CYP3A4 inhibitor is discontinued, think about growing the acetaminophen and codeine phosphate tablets dosage till stable drug results are obtained. Evaluate for indications of opioid withdrawal.
Parenteral drug abuse is often associated with transmission of infectious diseases which include hepatitis and HIV.
Accidental Ingestion Accidental ingestion of even 1 dose of acetaminophen and codeine phosphate tablets, Specifically by young children, may lead to a deadly overdose of acetaminophen and codeine (see WARNINGS).
Instruct people never to share acetaminophen and codeine phosphate tablets with others and to choose actions to protect more info acetaminophen and codeine phosphate tablets from theft or misuse.
Focus on with the patient and caregiver the availability of naloxone for that unexpected emergency cure of opioid overdose, both equally when initiating and renewing cure with acetaminophen and codeine phosphate tablets. Advise individuals and caregivers about the assorted strategies to click here acquire naloxone as permitted by unique point out naloxone dispensing check here and prescribing prerequisites or tips (e.
Discontinuation of a concomitantly read more utilized cytochrome P450 2D6 inhibitor may result in a reduce check here in codeine plasma concentration and a rise in Lively metabolite morphine plasma focus which could enhance or extend adverse reactions and may cause probably fatal respiratory despair.
Expecting or planning to come to be Expecting. Prolonged usage of Acetaminophen and Codeine Phosphate Tablets, USP through pregnancy could cause withdrawal symptoms as part of your newborn toddler that would be existence-threatening if not identified and handled.
The concomitant use of anticholinergic prescription drugs may improve threat of urinary retention and/or critical constipation, which can produce paralytic ileus.